Adrenergic nervous system in heart failure: pathophysiology and therapy

A Lymperopoulos, G Rengo, WJ Koch - Circulation research, 2013 - Am Heart Assoc
Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College …

2005 Writing Committee Members, SA Hunt… - Circulation, 2009 - Am Heart Assoc
It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

[图书][B] Miller's anesthesia e-book

RD Miller, LI Eriksson, LA Fleisher, JP Wiener-Kronish… - 2014 - books.google.com
From fundamental principles to advanced subspecialty procedures, Miller's Anesthesia
covers the full scope of contemporary anesthesia practice. This go-to medical reference …

The sympathetic nervous system in heart failure: physiology, pathophysiology, and clinical implications

F Triposkiadis, G Karayannis, G Giamouzis… - Journal of the American …, 2009 - jacc.org
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers
countermeasures aimed to restore cardiac output. These responses are compensatory at …

ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American …

Writing Committee Members, SA Hunt, WT Abraham… - circulation, 2005 - Am Heart Assoc
Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are …

Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress

DS Charney - American journal of Psychiatry, 2004 - Am Psychiatric Assoc
OBJECTIVE: Most research on the effects of severe psychological stress has focused on
stress-related psychopathology. Here, the author develops psychobiological models of …

Genetic mutations and mechanisms in dilated cardiomyopathy

EM McNally, JR Golbus… - The Journal of clinical …, 2013 - Am Soc Clin Investig
Genetic mutations account for a significant percentage of cardiomyopathies, which are a
leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac …

Progress and promise of genome-wide association studies for human complex trait genetics

BE Stranger, EA Stahl, T Raj - Genetics, 2011 - academic.oup.com
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …

Prioritizing GWAS results: a review of statistical methods and recommendations for their application

RM Cantor, K Lange, JS Sinsheimer - The American Journal of Human …, 2010 - cell.com
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

What is the role of β-adrenergic signaling in heart failure?

MJ Lohse, S Engelhardt, T Eschenhagen - Circulation research, 2003 - Am Heart Assoc
This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …