ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
APOE4 is the strongest genetic risk factor for Alzheimer's disease,–. However, the effects of
APOE4 on the human brain are not fully understood, limiting opportunities to develop …
APOE4 on the human brain are not fully understood, limiting opportunities to develop …
Comparison and evaluation of statistical error models for scRNA-seq
S Choudhary, R Satija - Genome biology, 2022 - Springer
Background Heterogeneity in single-cell RNA-seq (scRNA-seq) data is driven by multiple
sources, including biological variation in cellular state as well as technical variation …
sources, including biological variation in cellular state as well as technical variation …
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …
[HTML][HTML] TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4
In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …
Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
IS Fetahu, W Esser-Skala, R Dnyansagar… - Nature …, 2023 - nature.com
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
D Lara-Astiaso, A Goñi-Salaverri, J Mendieta-Esteban… - Nature …, 2023 - nature.com
Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
MI Gabitto, KJ Travaglini, VM Rachleff… - Research …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …