Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Compensatory mechanisms in Parkinson's disease: circuits adaptations and role in disease modification
The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
T Fieblinger, SM Graves, LE Sebel, C Alcacer… - Nature …, 2014 - nature.com
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson's disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction in the
number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 …
number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 …
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
R Martín, R Bajo-Grañeras, R Moratalla, G Perea… - Science, 2015 - science.org
Astrocytes are important regulatory elements in brain function. They respond to
neurotransmitters and release gliotransmitters that modulate synaptic transmission …
neurotransmitters and release gliotransmitters that modulate synaptic transmission …
Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications
MA Cenci - Frontiers in neurology, 2014 - frontiersin.org
The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's
disease (PD) for over 40 years. However, the response to this treatment changes with …
disease (PD) for over 40 years. However, the response to this treatment changes with …
Striatal synapses, circuits, and Parkinson's disease
Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
[HTML][HTML] Striatal glutamatergic hyperactivity in Parkinson's disease
F Campanelli, G Natale, G Marino, V Ghiglieri… - Neurobiology of …, 2022 - Elsevier
Glutamatergic hyperactivity in the nucleus striatum, the main basal ganglia input, has been
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …