Cellular senescence: the good, the bad and the unknown

W Huang, LTJ Hickson, A Eirin, JL Kirkland… - Nature Reviews …, 2022 - nature.com
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Immunosenescence: a key player in cancer development

J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Skin senescence: mechanisms and impact on whole-body aging

AC Franco, C Aveleira, C Cavadas - Trends in molecular medicine, 2022 - cell.com
The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Role of p53 in the regulation of cellular senescence

M Mijit, V Caracciolo, A Melillo, F Amicarelli… - Biomolecules, 2020 - mdpi.com
The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Therapy-induced senescence: opportunities to improve anticancer therapy

PG Prasanna, DE Citrin, J Hildesheim… - JNCI: Journal of the …, 2021 - academic.oup.com
Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …

[HTML][HTML] Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

WS Harris, NL Tintle, F Imamura, F Qian… - Nature …, 2021 - nature.com
The health effects of omega-3 fatty acids have been controversial. Here we report the results
of a de novo pooled analysis conducted with data from 17 prospective cohort studies …

Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

M Ogrodnik - Aging cell, 2021 - Wiley Online Library
The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Hallmarks of senescence and aging

S Dodig, I Čepelak, I Pavić - Biochemia medica, 2019 - hrcak.srce.hr
Sažetak The complex process of biological aging, as an intrinsic feature of living beings, is
the result of genetic and, to a greater extent, environmental factors and time. For many of the …