BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …

Long-term outcome for patients with high-grade osteosarcoma has improved with the
addition of systemic chemotherapy, but subsequent progress has been less marked …

Objective To determine the availability of data on overall survival and quality of life benefits
of cancer drugs approved in Europe. Design Retrospective cohort study. Setting Publicly …

Background Regorafenib has proven activity in patients with pretreated gastrointestinal
stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to …

Background Results of previous study showed promising but short-lived activity of sorafenib
in the treatment of patients with unresectable advanced and metastatic osteosarcoma. This …

Background High-grade osteosarcoma is a primary malignant bone tumour mainly affecting
children and young adults. The European and American Osteosarcoma Study (EURAMOS) …

This document is an update of the British Sarcoma Group guidelines published in 2010. The
aim is to provide a reference standard for the clinical care of patients in the UK with bone …

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and
dogs, although the disease occurs in dogs approximately 10 times more frequently than in …

Osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma are the most common malignant
musculoskeletal tumors in children and adolescents. Today, most patients can be cured …

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute
a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma …