Background RUNX1 is a transcription factor and a master regulator for the specification of
the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis …

Systemic immune responses caused by chronic hypercholesterolaemia contribute to
atherosclerosis initiation, progression and complications. However, individuals often change …

ABSTRACT Introduction Systemic Lupus Erythematosus (SLE) is a multi-dimensional
autoimmune disease involving numerous tissues throughout the body. The chromatin …

Familial platelet disorder (FPD) is associated with germline RUNX1 mutations, establishing
a preleukemic state and increasing the risk of developing leukemia. Currently, there are no …

Platelet α-granules have numerous proteins, some synthesized by megakaryocytes (MK)
and others not synthesized but incorporated by endocytosis, an incompletely understood …

Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid
malignancies. However, it is unknown whether sustained innate immune signaling …

Background Endometriosis is a common cause of endometrial-type mucosa outside the
uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with …

Takayasu arteritis (TAK) is a rare vasculitis characterized by inflammation of large arteries.
Although the exact etiology of TAK remains unclear, a genetic predisposition to the disease …

Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer
and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor …

Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the
elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) …