Advances in brain epitranscriptomics research and translational opportunities

F Zhang, VV Ignatova, G Ming, H Song - Molecular psychiatry, 2024 - nature.com
Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged
as crucial regulators of RNA metabolism, attracting significant interest from both basic and …

RNA editing in disease: mechanisms and therapeutic potential

KH Tamizkar, MF Jantsch - RNA, 2025 - rnajournal.cshlp.org
Adenosine to inosine conversion by ADARs was first identified in the late eighties of the
previous century. As the conversion of adenosines to inosines can be easily detected by …

RNA editing enzymes: structure, biological functions and applications

D Zhang, L Zhu, Y Gao, Y Wang, P Li - Cell & Bioscience, 2024 - Springer
With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

ADR-2 regulates fertility and oocyte fate in Caenorhabditis elegans

EA Erdmann, M Forbes, M Becker, S Perez… - Genetics, 2024 - academic.oup.com
RNA-binding proteins (RBPs) play essential roles in coordinating germline gene expression
and development in all organisms. Here, we report that loss of ADR-2, a member of the …

[HTML][HTML] Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1 Knockout Mice

L Zerad, N Gacem, F Gayda, L Day, K Sinigaglia… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Adenosine deaminase acting on RNA 1 (ADAR1) is the principal enzyme for the adenosine-
to-inosine RNA editing that prevents the aberrant activation of cytosolic nucleic acid sensors …

Potential usages of A-to-I RNA editing patterns as diagnostic biomarkers

D Rodriguez Morales, M Ilieva… - American Journal of …, 2023 - journals.physiology.org
Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications
found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing …

American Journal of Physiology-Cell Physiology in 2022: at a glance

E Delpire, TJ Hawke, M Karthikeyan… - … of Physiology-Cell …, 2023 - journals.physiology.org
We worked on a continuous stream of high-quality manuscripts, and we received almost 600
submissions as of New Year's Eve! The editors would like to take this opportunity to share …

ADR-2 regulates fertility and oocyte fate in C. elegans

EA Erdmann, M Forbes, M Becker, S Perez… - …, 2024 - pmc.ncbi.nlm.nih.gov
RNA binding proteins play essential roles in coordinating germline gene expression and
development in all organisms. Here, we report that loss of ADR-2, a member of the …

[HTML][HTML] The future of complement therapeutics

M Kolev, KN Rao, M Yeh, A Parikh… - Exploration of …, 2024 - explorationpub.com
Complement is both evolutionary and scientifically old. It predates the adaptive immunity by
some 600 million years and was first described in 1905 by Jules Bordet and Paul Ehrlich …

Eric Delpire1, Thomas Hawke2, Mythreye Karthikeyan3, Wei Kong4, Alexander 6

SU Nyström, L Schaefer - journals.physiology.org
The year 2022 was a very good year for the American Journal of Physiology-Cell 55
Physiology (AJP-Cell Physiology). We worked on a continuous stream of high-quality 56 …