Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

The injured spinal cord does not heal properly. In contrast, tissue repair and functional
recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is …

Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects
thousands of human beings, and the pathologic changes after injury have been a hot spot …

Significance: Traumatic brain injury (TBI) and spinal cord injury (SCI) are major causes of
death and long-term disability worldwide. Despite important pathophysiological differences …

Spinal cord injury results in a life‐disrupting series of deleterious interconnected
mechanisms encompassed by the primary and secondary injury. These events are mediated …

In response to NIH initiatives to investigate sex as a biological variable in preclinical animal
studies, researchers have increased their focus on male and female differences in …

Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with
multiple functions in the brain during development and in adulthood. The inflammatory …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

Autophagy is a physiological process that helps maintain a balance between the
manufacture of cellular components and breakdown of damaged organelles and other toxic …