Gut microbial metabolism is intimately coupled with host health and disease. Aromatic
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …

Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

Schizophrenia remains a major health burden, highlighting the need for new treatment
approaches. We consider the potential for targeting the trace amine (TA) system. We first …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …

Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …

Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …

Atypical antipsychotic drugs were introduced in the early 1990s. Unlike typical
antipsychotics, which are effective only against positive symptoms of schizophrenia, atypical …

TAAR1 is widely expressed across the mammalian brain, particularly in limbic and
monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction …

The studies of psychedelics, especially psychedelic tryptamines like psilocybin, are rapidly
gaining interest in neuroscience research. Much of this interest stems from recent clinical …