Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has
multifactorial aetiology with complex interactions between genetic and environmental …

The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even
more difficult to decipher the pathophysiology to explain for the similarities and differences …

Summary Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg)
cells are each independently required to maintain immune tolerance. Here we show that IL …

The impact of gut microbiota in eliciting innate and adaptive immune responses beneficial
for the host in the context of effective therapies against cancer has been highlighted recently …

Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is
characterized by chronic intestinal inflammation due to a complex interaction of genetic …

Crohn's disease and ulcerative colitis, together known as inflammatory bowel disease, are
debilitating chronic disorders of unknown cause and cure. Our evolving understanding of …

Abstract Mutations in Wiskott–Aldrich syndrome protein (WASP) cause autoimmune
sequelae including colitis. Yet, how WASP mediates mucosal homeostasis is not fully …

The pathogenesis of pediatric inflammatory bowel disease (IBD) is only partially understood.
Strong evidence implicates a strong genetic component including high monozygotic twin …

Inflammatory bowel disease (IBD) is a multifactoral disease caused by dysregulated immune
responses to commensal or pathogenic microbes in the intestine, resulting in chronic …

Mutations in Wiskott-Aldrich syndrome (WAS) protein (WASp), a regulator of actin dynamics
in hematopoietic cells, cause WAS, an X-linked primary immunodeficiency characterized by …