Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Heparan sulfate proteoglycans and viral attachment: true receptors or adaptation bias?

V Cagno, ED Tseligka, ST Jones, C Tapparel - Viruses, 2019 - mdpi.com
Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged
heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular …

Picornavirus and enterovirus diversity with associated human diseases

C Tapparel, F Siegrist, TJ Petty, L Kaiser - Infection, Genetics and Evolution, 2013 - Elsevier
Members of the Picornaviridae family are non-enveloped, positive-stranded RNA viruses
with a 30nm icosahedral capsid. This virus family exhibits a considerable amount of genetic …

COPD exacerbations: defining their cause and prevention

JA Wedzicha, TAR Seemungal - The lancet, 2007 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Increased risk of myocardial infarction and stroke following exacerbation of COPD

GC Donaldson, JR Hurst, CJ Smith, RB Hubbard… - Chest, 2010 - Elsevier
Objective Patients with COPD are at risk for cardiovascular events. This is attributed to
increased systemic inflammation. The course of COPD is punctuated by exacerbations …

Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease

T Seemungal, R Harper-Owen, A Bhowmik… - American journal of …, 2001 - atsjournals.org
The effects of respiratory viral infection on the time course of chronic obstructive pulmonary
disease (COPD) exacerbation were examined by monitoring changes in systemic …

Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease

TMA Wilkinson, GC Donaldson, JR Hurst… - American journal of …, 2004 - atsjournals.org
Treatment of chronic obstructive pulmonary disease (COPD) exacerbations improves
outcomes; however, responses to treatment are variable, and patients with COPD often …

Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells

Q Wu, D Jiang, M Minor, HW Chu - PloS one, 2014 - journals.plos.org
Background/Objective The use of electronic cigarettes (e-cigarettes) is rapidly increasing in
the United States, especially among young people since e-cigarettes have been perceived …

Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations

IS Patel, TAR Seemungal, M Wilks, SJ Lloyd-Owen… - Thorax, 2002 - thorax.bmj.com
Background: Patients with chronic obstructive pulmonary disease (COPD) are prone to
frequent exacerbations which are a significant cause of morbidity and mortality. Stable …

Air pollution and respiratory viral infection

J Ciencewicki, I Jaspers - Inhalation toxicology, 2007 - Taylor & Francis
Despite current regulations, which limit the levels of certain air pollutants, there are still a
number of adverse health effects that result from exposure to these agents. Numerous …