Multicellular systems, such as epithelial cell collectives, undergo transitions similar to those
in inert physical systems like sand piles and foams. To remodel or maintain tissue …

Migration of endothelial and many other cells requires spatiotemporal regulation of
protrusive and contractile cytoskeletal rearrangements that drive local cell shape changes …

Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …

The KRAS gene is nearly ubiquitously subjected to activating mutation in pancreatic
adenocarcinomas (PDAC), occurring at a frequency of over 90% in tumors. Mutant KRAS …

BACKGROUND: Many specialized cells in adult organs acquire a state of cell cycle arrest
and quiescence through unknown mechanisms. Our limited understanding of mammalian …

The cellular cortex provides crucial mechanical support and plays critical roles during cell
division and migration. The proteins of the ERM family, comprised of ezrin, radixin, and …

Animal cells undergo repeated shape changes, for example by rounding up and
respreading as they divide. Cell rounding can be also observed in interphase cells, for …

Bone health is controlled by the balance between bone formation by osteoblasts and
degradation by osteoclasts. A disequilibrium in favor of bone resorption leads to osteolytic …

Polarised epithelial cell divisions represent a fundamental mechanism for tissue
maintenance and morphogenesis. Morphological and mechanical changes in the plasma …

Gaining insight into osmotic pressure and its biological implications is pivotal for revealing
mechanisms underlying numerous fundamental biological processes across scales and will …