Depression is a global threat to mental health that affects around 264 million people
worldwide. Despite the considerable evolution in our understanding of the pathophysiology …

Abstract Ethnopharmacological relevance Radix Polygalae (RP) has been traditionally used
for the treatment of various psychiatric disorders in East Asia. Aim of the study Depression is …

Abstract Tryptophan (Trp), an α‐amino acid, is the precursor of serotonin (5‐
hydroxytryptamine, 5‐HT), which is involved in a variety of features of metabolic function and …

A therapeutic strategy through the gut–brain axis has been proven to be effective in
treatment for depression. In our previous study, we demonstrated that Enterococcus faecalis …

An olfactory bulbectomy (OBX) rodent is a widely-used model for depression (especially for
agitated depression). The present study aims to investigate the hippocampus metabolic …

The heavy use of agrochemicals is considered a major factor contributing to the decline in
wild honeybee populations. Development of low-toxicity enantiomers of chiral fungicides is …

The increasing number of people with depression worldwide has led to concerns regarding
antidepressant contamination in aquatic environments, which could have the risk of negative …

Chaigui granules were a traditional Chinese medicine (TCM) preparation with
antidepressant effects derived from a famous antidepressant prescription. It was of great …

Background Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the
most commonly used for the treatment of major depression. However, they are effective for …

Chronic stressors represented risk factors for the etiology or exacerbation of several
gastrointestinal diseases. The goal of the present study was to examine whether chronic …