A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The Eigth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT VII, took place in
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …

Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

This review summarizes the importance and recent discoveries of the use of adamantane
derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) …

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia
(OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central …

Diamondoid molecules are cage-like, ultrastable, saturated hydrocarbons. These molecules
are ringed compounds, which have a diamond-like structure consisting of a number of six …

Spiro [aziridine-2, 2′-adamantanes] 1 and 2, spiro [azetidine-2, 2′-adamantanes] 3 and 5,
spiro [azetidine-3, 2′-adamantane] 13, spiro [piperidine-4, 2′-adamantanes] 25 and 27 …

Pregabalin 1 was recently approved in the US and Europe as an add-on therapy for
epilepsy, as well as for the treatment of neuropathic pain (specifically, management of …

Voltage-gated calcium (CaV) channels are transmembrane proteins that form Ca2+-
selective pores gated by depolarization and are essential regulators of the intracellular …

Epilepsy is the most common neurological condition and cause of substantial morbidity and
mortality. In the present study, the molecular hybridization tool was adopted to obtain six …