The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

Cognitive control is subjectively costly, suggesting that engagement is modulated in
relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine …

Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode
reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the …

Adolescence represents a key period of brain development underpinned by the ongoing
maturation of the prefrontal cortex—a brain region involved in the regulation of behaviour …

Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from
differences in intrinsic properties and connectivity to selective task engagement in behaving …

Many debilitating neuropsychiatric and neurodegenerative disorders are characterized by
dopamine neurotransmitter dysregulation. Monitoring subsecond dopamine release …

It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …

Ca2+-influx through L-type Ca2+-channels (LTCCs) is associated with activity-related
stressful oscillations of Ca2+ levels within dopaminergic (DA) neurons in the substantia …

Gilles de la Tourette syndrome is a hereditary, neuropsychiatric movement disorder with
reported abnormalities in the neurotransmission of dopamine and γ-aminobutyric acid …