E-cadherin and P-cadherin are major contributors to cell–cell adhesion in epithelial tissues,
playing pivotal roles in important morphogenetic and differentiation processes during …

Cell–cell connectivity is an absolute requirement for the correct functioning of cells, tissues
and entire organisms. At the level of the individual cell, direct cell–cell adherence and …

MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal
and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling …

The transcription factor p63 plays a pivotal role in keratinocyte proliferation and
differentiation in the epidermis. However, how p63 regulates epidermal genes during …

P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in
several normal tissues. However, its behaviour in the malignant setting is notably dependent …

Epithelial-mesenchymal transition (EMT) is a physiological process that plays important
roles in tumor metastasis," stemness," and drug resistance. EMT is typically characterized by …

Abstract Background Sweat glands (SGs) and hair follicles (HFs) are two important
cutaneous appendages that play crucial roles in homeostatic maintenance and …

The transcription factor p63 is essential for the formation of the epidermis and other
stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient …

Generalized pustular psoriasis (GPP) is a rare, potentially life threatening, and aggressive
form of psoriasis, which is characterized by sudden onset with repeated episodic skin …

ABSTRACT P-cadherin is a cell-cell adhesion molecule, whose expression is highly
associated with undifferentiated cells in normal adult epithelial tissues, as well as with poorly …