Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

The global emergence of carbapenemase-producing bacteria capable of hydrolyzing the
once effective carbapenem antibiotics is considered a contemporary public health concern …

Background Klebsiella species, including the notable pathogen K. pneumoniae, are
increasingly associated with antimicrobial resistance (AMR). Genome-based surveillance …

Introduction Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam
antibiotics, including carbapenems. Carbapenemase production in Enterobacterales …

The emergence of Klebsiella pneumoniae isolates carrying novel bla KPC variants
conferring ceftazidime-avibactam (CAZ/AVI) resistance is being increasingly reported. We …

The rapid spread of carbapenemase-producing Klebsiella pneumoniae (cpKP) poses
serious threats to public health; however, the underlying genetic basis for its dissemination …

Outer membrane porins in Gram-negative bacteria facilitate antibiotic influx. In Klebsiella
pneumoniae, modifications in the porin OmpK36 are implicated in increasing resistance to …

The spread of carbapenemase-producing Enterobacteriaceae (CPE), contributing to
widespread carbapenem resistance, has become a global concern. However, the specific …

Mutations in outer membrane porins act in synergy with carbapenemase enzymes to
increase carbapenem resistance in the important nosocomial pathogen, Klebsiella …