Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic
whose etiology reflects multiple interactions between environmental and genetic factors …

White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …

The NanoString RNA counting assay for formalin-fixed paraffin embedded samples is
unique in its sensitivity, technical reproducibility and robustness for analysis of clinical and …

Abstract Type 2 diabetes (T2D) is highly prevalent and is a strong contributor for
cardiovascular disease. However, there is significant heterogeneity in disease pathogenesis …

A challenge of next generation sequencing is read contamination. We use Genotype-Tissue
Expression (GTEx) datasets and technical metadata along with RNA-seq datasets from other …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

Background Obesity predisposes individuals to multiple cardiometabolic disorders,
including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat …

Background COVID-19 severity varies widely. Although some demographic and cardio-
metabolic factors, including age and obesity, are associated with increasing risk of severe …

Background Expression quantitative trait loci (eQTL) studies provide insights into regulatory
mechanisms underlying disease risk. Expanding studies of gene regulation to …