Elimination of tissue viral reservoirs is likely the key to generation of an effective HIV cure.
Exciting studies have come out recently that reveal crucial insights into topics ranging from …

Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in
infants, immunocompromised individuals, and older individuals. There is an urgent need for …

Lifelong treatment is required for people living with HIV as current antiretroviral therapy
(ART) does not eradicate HIV infection. Latently infected cells are essentially …

CD4+ T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular
immunity and opportunistic infections, but its contribution to SIV/HIV-associated gut …

The rebound competent viral reservoir (RCVR)–virus that persists during antiretroviral
treatment (ART) and can reignite systemic infection when treatment is stopped–is the …

TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell
activation and proliferation. Resting HIV-1 target cells represent the main cellular reservoir …

Understanding the underlying mechanisms of HIV pathogenesis is critical for designing
successful HIV vaccines and cure strategies. However, achieving this goal is complicated by …

The capacity of HIV-1 to replicate during optimal antiretroviral therapy (ART) is challenging
to assess directly. To gain greater sensitivity to detect evolution on ART, we used a …

Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in
evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART …

Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment
control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an …