Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Highlights•Degraders are an emerging modality which fall into the 'beyond rule of
5'space.•Poor permeability and solubility are critical features limiting oral absorption.• …

The development of a drug-resistant cell line can take from 3 to 18 months. However, little is
published on the methodology of this development process. This article will discuss key …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

Berberine chloride (BBR) is a natural isoquinoline alkaloid extracted from medicinal herbs. It
has been reported that the intestinal absorption of BBR is very low. In this study, the absolute …

Importance of the field: The use of traditional medicines of natural origin is being
encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may …

The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human
permeability but suffering from several and critical limitations. Therefore, some alternative …

Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a …

Solubility and permeability being important determinants of oral drug absorption, this study
was aimed to investigate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate …