From therapy to experimental model: a hundred years of endotoxin administration to human subjects

M Bahador, AS Cross - Journal of Endotoxin Research, 2007 - journals.sagepub.com
This article is a review of studies in which endotoxin has been administered to human
subjects for experimental purposes. Data are presented in tabular form so the reader can …

Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases

PN Patel, RY Shah, JF Ferguson… - … thrombosis, and vascular …, 2015 - Am Heart Assoc
Inflammation is a fundamental feature of several complex cardiometabolic diseases. Indeed,
obesity, insulin resistance, metabolic dyslipidemia, and atherosclerosis are all closely linked …

Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results

A Ameri, N Rahnama, R Bozorgmehr… - International Journal of …, 2020 - Elsevier
Purpose The COVID-19 outbreak is affecting people worldwide. Many infected patients have
respiratory involvement that may progress to acute respiratory distress syndrome. This pilot …

Low-dose whole-lung irradiation for COVID-19 pneumonia: Final results of a pilot study

A Ameri, P Ameri, N Rahnama, M Mokhtari… - International Journal of …, 2021 - Elsevier
Introduction Radiation therapy (RT), commonly used in cancer management, has been
considered as one of the potential treatments for COVID-19 pneumonia. Here, we present …

Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases?

M Bennermo, C Held, S Stemme, CG Ericsson… - Clinical …, 2004 - academic.oup.com
Background: A single-nucleotide polymorphism (SNP) in the promoter region of the
interleukin-6 (IL-6) gene at position− 174 (G> C) has been reported to be associated with a …

α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB …

SH Jung, SJ Kim, BG Jun, KT Lee, SP Hong… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The rhizomes of Cyperus rotundus
(Cyperaceae) have been used in Asian traditional medicine for the treatment of several …

Simvastatin prevents vascular hyporeactivity during inflammation

J Pleiner, G Schaller, F Mittermayer, S Zorn, C Marsik… - Circulation, 2004 - Am Heart Assoc
Background—There is growing evidence that statins exert anti-inflammatory and
antioxidative vascular actions that are independent of lipid lowering. We tested whether …

Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments

AE Jones, JA Kline - Critical care medicine, 2005 - journals.lww.com
The treatment of patients with severe sepsis and septic shock (collectively referred to as
sepsis) continues to evolve. Recent studies have promulgated the benefit of early goal …

Association of IL-10 (-819T/C,-592A/C and-1082A/G) and IL-6-174G/C gene polymorphism and the risk of pneumonia-induced sepsis

ZR Mao, SL Zhang, B Feng - Biomarkers, 2017 - Taylor & Francis
Context: Association between inherited variants and the risks of sepsis is controversial.
Objective: To evaluate the risk of pneumonia-induced sepsis by examining its linkage with …

A randomized controlled trial of the effects of febuxostat therapy on adipokines and markers of kidney fibrosis in asymptomatic hyperuricemic patients with diabetic …

S Beddhu, R Filipowicz, B Wang… - Canadian journal of …, 2016 - journals.sagepub.com
Background: In observational studies, higher uric acid levels are associated with metabolic
syndrome, diabetes, and kidney disease. Objective: The objective of this study is to examine …