Oxidative stress, caused by an imbalance between the production and the accumulation of
reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our
society. It is becoming increasingly prevalent, especially in developed countries, due to the …

Background Oxidative stress is a crucial factor leading to subarachnoid hemorrhage (SAH)-
induced early brain injury (EBI). Isoliquiritigenin has been verified as a powerful anti-oxidant …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

Emerging evidence from Alzheimer's disease (AD) patients suggests that reducing tau
pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the main
cause of dementia worldwide. As the pathogenesis of AD is quite complicated, there is …

The deposition of β-amyloid (Aβ) plaques in the parenchymal and cortical regions of the
brain of Alzheimer's disease (AD) patients is considered the foremost pathological hallmark …

Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
most prevalent neurodegenerative disease worldwide. The primary pathological hallmarks …