Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

SR Salpeter, E Greyber, GA Pasternak… - … of systematic reviews, 2010 - cochranelibrary.com
Background Metformin is an oral anti‐hyperglycemic agent that has been shown to reduce
total mortality compared to other anti‐hyperglycemic agents, in the treatment of type 2 …

Is metformin a perfect drug? Updates in pharmacokinetics and pharmacodynamics

M Markowicz-Piasecka, KM Huttunen… - Current …, 2017 - ingentaconnect.com
Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …

Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum …

EC Widjajakusuma, A Jonosewojo, L Hendriati… - Phytomedicine, 2019 - Elsevier
Background Our previous preclinical study showed that the extract mixture (EM) of
Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) and Syzygium polyanthum (Wight.) …

A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?

K Maniar, A Moideen, A Mittal, A Patil… - Pharmacological …, 2017 - Elsevier
The most widely prescribed oral anti-diabetic agent today in the world today is a member of
the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently …

Global dependence on Corn Belt Dent maize germplasm: Challenges and opportunities

JS Smith, W Trevisan, A McCunn, WE Huffman - Crop Science, 2022 - Wiley Online Library
Many changes affecting the management of genetic diversity occurred following
recommendations made by the National Research Council in the aftermath of the Southern …

Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review

N Hedayati, Z Oskouei, J Tabeshpour… - European Journal of …, 2021 - Elsevier
Nutraceuticals are principally extracted from natural products that are frequently safe and
well-tolerated. Lycopene and berberine are natural plants with a wide range of beneficial …

Acute effect of metformin on postprandial hypertriglyceridemia through delayed gastric emptying

D Sato, K Morino, F Nakagawa, K Murata… - International journal of …, 2017 - mdpi.com
Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention
in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma …

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats

US Ekperikpe, S Mandal, SJ Holt… - American Journal …, 2023 - journals.physiology.org
Prepubertal obesity is currently an epidemic and is considered as a major risk factor for
renal injury. Previous studies have demonstrated that insulin resistance contributes to renal …

[PDF][PDF] Levels of myeloperoxidase, malondialdehyde and lipid profile in type 2 diabetic patients on metformin versus glibenclamide therapy

ZH Fathi, JA Mohammad, MH Mohammed - Age (years), 2020 - researchgate.net
Introduction: In diabetes mellitus, oxidative stress plays a major role in the development and
progression of cardiovascular complications. Atherogenic index of plasma is a novel marker …

Effect of metformin on blood pressure in patients with hypertension: a randomized clinical trial

VC Júnior, FD Fuchs, BD Schaan, LB Moreira… - Endocrine, 2019 - Springer
Objective Part of the beneficial effects of metformin on the prevention of cardiovascular
events in diabetes can be attributed to pleiotropic effects, including a blood pressure (BP) …