Biomarkers in autism

AAS Goldani, SR Downs, F Widjaja, B Lawton… - Frontiers in …, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are complex, heterogeneous disorders caused by an
interaction between genetic vulnerability and environmental factors. In an effort to better …

Biomarkers for major depressive and bipolar disorders using metabolomics: A systematic review

K MacDonald, A Krishnan, E Cervenka… - American Journal of …, 2019 - Wiley Online Library
Major depressive disorder (MDD) and bipolar disorder (BD) lack robust biomarkers useful
for screening purposes in a clinical setting. A systematic review of the literature was …

Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis

A Seyedsalehi, V Warrier, RAI Bethlehem, BI Perry… - Brain, 2023 - academic.oup.com
Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors

M Notaras, A Lodhi, H Fang, D Greening… - Translational …, 2021 - nature.com
Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but
otherwise maintains unknown disease origins. Unfortunately, little progress has been made …

Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Lipids as biomarkers of brain disorders

G Hussain, H Anwar, A Rasul, A Imran… - Critical reviews in …, 2020 - Taylor & Francis
Brain is a central and pivotal organ of human body containing the highest lipids content next
to adipose tissue. It works as a monitor for the whole body and needs an adequate supply of …

Biomarkers of psychiatric diseases: current status and future prospects

M Kalia, JC e Silva - Metabolism, 2015 - Elsevier
Abnormal behavior and disturbed cognition, often assumed to represent psychiatric illness,
may actually result from some form of occult organic brain disease that can be detected by …

Applications of blood-based protein biomarker strategies in the study of psychiatric disorders

MK Chan, MG Gottschalk, F Haenisch, J Tomasik… - Progress in …, 2014 - Elsevier
Major psychiatric disorders such as schizophrenia, major depressive and bipolar disorders
are severe, chronic and debilitating, and are associated with high disease burden and …

Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study

DK Solberg, H Bentsen, H Refsum, OA Andreassen - BMC psychiatry, 2016 - Springer
Background Alterations in serum and membrane lipids may be involved in schizophrenia
pathophysiology. It is not known whether lipid profiles are associated with disease severity …

A pilot proteomic analysis of salivary biomarkers in autism spectrum disorder

AG Ngounou Wetie, KL Wormwood, S Russell… - Autism …, 2015 - Wiley Online Library
Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–
1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments …