Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

When a human cell detects damaged DNA, it initiates the DNA damage response (DDR) that
permits it to repair the damage and avoid transmitting it to daughter cells. Despite this …

The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block
the progression of DNA replication. DPCs frequently occur in cells, either as a consequence …

Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Hydroxyl radical (radical dot OH) and one-electron oxidants that may be endogenously
formed through oxidative metabolism, phagocytosis, inflammation and pathological …

A number of proteins form covalent bonds with DNA as obligatory transient intermediates in
normal nuclear transactions. Drugs that trap these complexes have proven to be potent …

DNA–protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-
repair mechanisms exist was until recently unknown. This has changed with discoveries …

Ionizing radiation produces various DNA lesions such as base damage, DNA single-strand
breaks (SSBs), DNA double-strand breaks (DSBs), and DNA–protein cross-links (DPCs). Of …

Enhancer activation serves as the main mechanism regulating signal-dependent
transcriptional programs, ensuring cellular plasticity, yet central questions persist regarding …