Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small
molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Macrophage cell fusion and multinucleation are fundamental processes in the formation of
multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Understanding the mechanism by which tumor cells influence osteoclast differentiation is
crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …

Small animals do not replicate the severity of the human foreign-body response (FBR) to
implants. Here we show that the FBR can be driven by forces generated at the implant …