All animals heal, and the ability to heal is requisite for human health. One aspect of repair
that has always been considered to be essential for adequate healing is the creation of a …

Wound healing is a complex, highly developed chain of events that allows people to interact
with their environment. The skin is a protective organ, and it provides vital functions like …

Wounds especially chronic ones significantly affect the quality of patients' life and present a
severe financial burden for the healthcare industry. Timely and effective management of …

1. Introduction Since its introduction in clinical practice in the early 1990's negative pressure
wounds therapy (NPWT) has become widely used in the management of complex wounds in …

Vacuum-assisted closure (VAC), sometimes referred to as microdeformational wound
therapy (MDWT) or negative pressure wound therapy (NPWT), has revolutionized wound …

Angiogenesis, or the growth of new blood vessels from the preexisting vasculature, is a
visible and important component of wound repair. When tissue damage occurs, disruption of …

Background Negative-pressure wound therapy (NPWT) promotes angiogenesis and
granulation, in part by strain-induced production of growth factors and cytokines. As their …

It has long been thought that the effectiveness and efficiency of physical therapy would
improve if our understanding of the cell biology/biochemistry that participates in mechanics …

A gastrointestinal (GI) transmural defect is defined as total rupture of the GI wall, and these
defects can be divided into three categories: perforations, leaks, and fistulas. Surgical …

Negative pressure wound therapy (NPWT), which was introduced as a commercial product
(VAC® Therapy, KCI USA, Inc., San Antonio, TX) less than 20 years ago, has revolutionised …