Artemisinin and its derivatives have become essential components of antimalarial treatment.
These plant-derived peroxides are unique among antimalarial drugs in killing the young …

A global resurgence of malaria has taken place as a result of a lapse in preventive efforts
and the emergence of resistance to standard antimalarial drugs. New therapies are …

Artemisinins were discovered to be highly effective antimalarial drugs shortly after the
isolation of the parent artemisinin in 1971 in China. These compounds combine potent …

Background Severe malaria results in over a million deaths every year, most of them in
children aged under five years and living in sub‐Saharan Africa. This review examines …

The emergence of resistance to former first-line antimalarial drugs has been an unmitigated
disaster. In recent years, artemisinin class drugs have become standard and they are …

Background To prevent child deaths from severe malaria, early parenteral treatment is
essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials …

Background Most malaria deaths occur in rural areas. Rapid progression from illness to
death can be interrupted by prompt, effective medication. Antimalarial treatment cannot …

The rectal route can be considered a good alternative to the oral route for the paediatric
population because these dosage forms are neither to be swallowed nor need to be taste …

The global challenge to the treatment of malaria is mainly the occurrence of resistance of
malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic …

The key to reducing malaria deaths in highly endemic areas is prompt access to quality case
management. Given that many severe cases occur at peripheral level, rectal artesunate …