HIV-1 and human genetic variation

PJ McLaren, J Fellay - Nature Reviews Genetics, 2021 - nature.com
Over the past four decades, research on the natural history of HIV infection has described
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …

The impact of host genetic variation on infection with HIV-1

PJ McLaren, M Carrington - Nature immunology, 2015 - nature.com
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …

Immunogenetics of HIV disease

MP Martin, M Carrington - Immunological reviews, 2013 - Wiley Online Library
Host genetic factors are a major contributing factor to the inter‐individual variation observed
in response to human immunodeficiency virus (HIV) infection and are linked to resistance to …

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

PJ McLaren, C Coulonges, S Ripke… - PLoS …, 2013 - journals.plos.org
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected
individuals, identifying common genetic influences on viral control and disease course …

G protein-coupled receptor (GPCR) pharmacogenomics

MD Thompson, D Reiner-Link, A Berghella… - Critical Reviews in …, 2024 - Taylor & Francis
The field of pharmacogenetics, the investigation of the influence of one or more sequence
variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline …

Interleukins and cytokine biomarkers in uveitis

S Balamurugan, D Das, M Hasanreisoglu… - Indian journal of …, 2020 - journals.lww.com
Interleukins and cytokines are involved in the pathogenesis of uveitis of heterogeneous
origin. Understanding the basics of the ocular immune privilege is a fulcrum to discern their …

[HTML][HTML] Prevention of SHIV transmission by topical IFN-β treatment

RS Veazey, HA Pilch-Cooper, TJ Hope, G Alter… - Mucosal …, 2016 - Elsevier
Understanding vaginal and rectal HIV transmission and protective cellular and molecular
mechanisms is critical for designing new prevention strategies, including those required for …

Pharmacogenetics of the G protein-coupled receptors

MD Thompson, DEC Cole, V Capra… - … in Drug Discovery and …, 2014 - Springer
Pharmacogenetics investigates the influence of genetic variants on physiological
phenotypes related to drug response and disease, while pharmacogenomics takes a …

Cytokines and biologics in non-infectious autoimmune uveitis: bench to bedside

R Agrawal, J Iyer, J Connolly, D Iwata… - Indian Journal of …, 2014 - journals.lww.com
Intraocular inflammatory eye disease is one of the important causes of ocular morbidity.
Even though the prevalence of uveitis is less common in relation to diabetic retinopathy …

Immunogenetics: Genome-Wide Association of Non-Progressive HIV and Viral Load Control: HLA Genes and Beyond

S Limou, JF Zagury - Frontiers in immunology, 2013 - frontiersin.org
Very early after the identification of the human immunodeficiency virus (HIV), host genetics
factors were anticipated to play a role in viral control and disease progression. As early as …