Background: The investigation of the cellular components, their interactions and related
functions constitute the major conditions in order to understand the cell as an integrated …

Herpes simplex virus type I (HSV-1) is the causative agent of several pathologies ranging in
severity from the common cold sore to life-threatening encephalitic infection. During …

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world
in which the capsids of alphaherpesviruses encounter viral and host proteins that support or …

Motivation: High-throughput methods for detecting molecular interactions have produced
large sets of biological network data with much more yet to come. Analogous to sequence …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

Herpesvirus capsids are assembled in the nucleus of infected cells whereas final maturation
occurs in the cytosol. To access the final maturation compartment, intranuclear capsids have …

Motivation: The interactions among proteins and the resulting networks of such interactions
have a central role in cell biology. Aligning these networks gives us important information …

Identifying the PPR-E+-NUWA-DYW2 editosome improves our understanding of the C-to-U
RNA editing in plant organelles. However, the mechanism of RNA editing remains to be …