Antimicrobial host defence peptides: functions and clinical potential
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …
occurring peptides that can combat infections through their direct microbicidal properties …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
[HTML][HTML] Antimicrobial peptides
The rapid increase in drug-resistant infections has presented a serious challenge to
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …
antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” …
Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …
[HTML][HTML] Designing antimicrobial peptides: form follows function
CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
Host defense peptides: front-line immunomodulators
SC Mansour, OM Pena, REW Hancock - Trends in immunology, 2014 - cell.com
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …
widely recognized for their multifunctional roles in both the innate and adaptive immune …
[HTML][HTML] Cathelicidins: immunomodulatory antimicrobials
RM Van Harten, E Van Woudenbergh, A Van Dijk… - Vaccines, 2018 - mdpi.com
Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions.
These effector molecules of the innate immune system of many vertebrates are diverse in …
These effector molecules of the innate immune system of many vertebrates are diverse in …
Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
AL Hilchie, K Wuerth, REW Hancock - Nature chemical biology, 2013 - nature.com
Cationic host defense (antimicrobial) peptides were originally studied for their direct
antimicrobial activities. They have since been found to exhibit multifaceted …
antimicrobial activities. They have since been found to exhibit multifaceted …
[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …
A comprehensive summary of LL-37, the factotum human cathelicidin peptide
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …
clear that they are an exceptional class of peptides, with some members having pleiotropic …