The concentration of biomolecules in living systems shows numerous systematic and
random variations. Systematic variations can be classified based on the frequency of …

Biological variation (BV) data have many applications in laboratory medicine. However,
these depend on the availability of relevant and robust BV data fit for purpose. BV data can …

Medical laboratory services enable precise measurement of thousands of biomolecules and
have become an inseparable part of high-quality healthcare services, exerting a profound …

Using laboratory test results for diagnosis and monitoring requires a reliable reference to
which the results can be compared. Currently, most reference data is derived from the …

Background Personalized reference intervals (prRIs) have the potential to improve
individual patient follow-up as compared to population-based reference intervals (popRI). In …

Biological variation (BV) is one of the most important sources contributing to uncertainty in
laboratory examinations and should be taken into account in any interpretation made. There …

Abstract Interpretation of laboratory data is a comparative procedure and requires reliable
reference data, which are mostly derived from population data but used for individuals in …

The diagnosis of diseases is a complex process involving the integration of multiple
parameters obtained from various sources, including laboratory findings. The interpretation …

Lessons in biostatistics Page 1 https://doi.org/10.11613/BM.2020.010101 Biochem Med (Zagreb)
2020;30(1):010101 1 Abstract Uncertainty is an inseparable part of all types of measurement …

Objectives Personalized reference intervals (prRI) have been proposed as a diagnostic tool
for assessing measurands with high individuality. Here, we evaluate clinical performance of …