S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of …

M Amoo, J Henry, PJ O'Halloran, P Brennan… - Neurosurgical …, 2022 - Springer
Biomarkers such as calcium channel binding protein S100 subunit beta (S100B), glial
fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCH-L1) and neuron …

Blood-based protein biomarkers for the management of traumatic brain injuries in adults presenting to emergency departments with mild brain injury: a living …

S Mondello, A Sorinola, E Czeiter, Z Vámos… - Journal of …, 2021 - liebertpub.com
Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and
intervention, but can be challenging in patients with mild TBI. A substantial number of …

Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter …

P Biberthaler, U Linsenmeier, KJ Pfeifer, M Kroetz… - Shock, 2006 - journals.lww.com
Ninety percent of patients with minor head injury (MHI) who have cranial computed
tomography (CCT) under the present clinical decision rules have normal scans. Serum …

Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury

T Hayakata, T Shiozaki, O Tasaki, H Ikegawa, Y Inoue… - Shock, 2004 - journals.lww.com
Abstract S100B protein (S100B) has been described as a marker of brain injury. Various
cytokines also increase in the cerebrospinal fluid (CSF) of patients with severe traumatic …

Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase

M Honda, R Tsuruta, T Kaneko… - Journal of Trauma …, 2010 - journals.lww.com
Background: Serum glial fibrillary acidic protein (GFAP) is a specific predictor of brain
damage and neurologic outcome in patients with traumatic brain injury (TBI). In this study …

S100-B protein as a screening tool for the early assessment of minor head injury

D Zongo, R Ribéreau-Gayon, F Masson… - Annals of emergency …, 2012 - Elsevier
STUDY OBJECTIVE: A computed tomography (CT) scan has high sensitivity in detecting
intracranial injury in patients with minor head injury but is costly, exposes patients to high …

Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis

J Undén, B Romner - The Journal of head trauma rehabilitation, 2010 - journals.lww.com
Can Low Serum Levels of S100B Predict Normal CT Findings Aft... : The Journal of Head
Trauma Rehabilitation Can Low Serum Levels of S100B Predict Normal CT Findings After Minor …

The addition of S100B to guidelines for management of mild head injury is potentially cost saving

O Calcagnile, A Anell, J Undén - BMC neurology, 2016 - Springer
Background Mild traumatic brain injury (TBI) is associated with substantial costs due to over-
triage of patients to computed tomography (CT) scanning, despite validated decision rules …

Extracranial sources of S100B do not affect serum levels

N Pham, V Fazio, L Cucullo, Q Teng, P Biberthaler… - PloS one, 2010 - journals.plos.org
S100B, established as prevalent protein of the central nervous system, is a peripheral
biomarker for blood-brain barrier disruption and often also a marker of brain injury. However …

Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury

JJ Bazarian, FP Zemlan, S Mookerjee, T Stigbrand - Brain injury, 2006 - Taylor & Francis
Primary objective: To determine the relationship of serum S-100B and C-tau levels to long-
term outcome after mild traumatic brain injury (mild TBI). Research design: A prospective …