Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …

The study of type 2 diabetes has been driven by advances in human genetics, epigenetics,
biomarkers, mechanistic studies, and large clinical trials, enabling new insights into disease …

The mammalian circadian system is a multi‐oscillator, hierarchically organised system
where a central pacemaker synchronises behavioural, physiological and gene expression …

The present study investigated the anti-diabetic activity and potential mechanism of
stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in …

Background Metformin has been available since 1957. Over 50 years later, one can
legitimately question whether a clear definition of its “therapeutic concentrations” is …

Background Understanding the genetic underpinnings of antidepressant treatment response
in unipolar major depressive disorder (MDD) can be useful in identifying patients at risk for …

Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or
first recognition during pregnancy. Women with a history of GDM are at long-term risk for …

Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk
factors for cardiovascular disease, and are destined to increase in importance given the …

Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin
resistance and progressively reduced insulin secretion, which leads to impaired glucose …