The roles of the hippocampus and prefrontal cortex (PFC) in memory processing—
individually or in concert—are a major topic of interest in memory research. These brain …

Endophenotypes, measurable components unseen by the unaided eye along the pathway
between disease and distal genotype, have emerged as an important concept in the study of …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

We examined the status of the neural network mediating the default mode of brain function,
which typically exhibits greater activation during rest than during task, in patients in the early …

The ability to regulate emotions is an important part of adaptive functioning in society.
Advances in cognitive and affective neuroscience and biological psychiatry have facilitated …

The complex organization of connectivity in the human brain is incompletely understood.
Recently, topological measures based on graph theory have provided a new approach to …

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

Relatively little is known about the long-term neurobiological sequelae of chronic stress,
which predisposes susceptible patients to neuropsychiatric conditions affecting the …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …