Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

Cell-to-cell heterogeneity drives a range of (patho) physiologically important phenomena,
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …