Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Several components of the GH axis are involved in tumor progression, and GH-induced
intracellular signaling has been strongly associated with breast cancer susceptibility in …

Much of our understanding of GH's action stems from animal models and the generation and
characterization of genetically altered or modified mice. Manipulation of genes in the …

Hepatocellular carcinoma (HCC) is an aggressive neoplasm with poor clinical outcome
because most patients present at an advanced stage, at which point curative surgical …

The growth hormone (GH) and insulin-like growth factor-1 (IGF1) axis is the key regulator of
longitudinal growth, promoting postnatal bone and muscle growth. The available data …

Results Compared with cirrhotic patients without HCC and healthy controls, cirrhotic patients
with HCC had significantly lower hepatic expression of GHR, STAT5, and IGF-1proteins …

Tumor development is a multistep process whereby local mechanisms enable somatic
mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ …

The epidermal growth factor receptor (EGFR) is a validated therapeutic target for triple-
negative breast cancer (TNBC). In the present study, we synthesize novel adamantanyl …

Pituitary derived and peripherally produced growth hormone (GH) is a crucial mediator of
longitudinal growth, organ development, metabolic regulation with tissue specific, sex …

Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver
cancers. It is an aggressive neoplasm with dismal outcome because most of the patients …