Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity

MK Owen, FA Witzmann, ML McKenney, X Lai… - Circulation, 2013 - Am Heart Assoc
Background—This investigation examined the mechanisms by which coronary perivascular
adipose tissue (PVAT)–derived factors influence vasomotor tone and the PVAT proteome in …

Association of nonalcoholic fatty liver disease with QTc interval in patients with type 2 diabetes

G Targher, F Valbusa, S Bonapace, L Bertolini… - Nutrition, Metabolism …, 2014 - Elsevier
Background and aims The relationship between nonalcoholic fatty liver disease (NAFLD)
and prolonged heart rate-corrected QT (QTc) interval, a risk factor for ventricular arrhythmias …

Sudden cardiac death and obesity

B Plourde, JF Sarrazin, I Nault… - Expert review of …, 2014 - Taylor & Francis
For individuals and the society as a whole, the increased risk of sudden cardiac death in
obese patients is becoming a major challenge, especially since obesity prevalence has …

Relation of Body Mass Index Categories with Risk of Sudden Cardiac Death A Systematic Review and Meta-Analysis

H Chen, Y Deng, S Li - International heart journal, 2019 - jstage.jst.go.jp
The aim of this study was to evaluate the association of the body mass index (BMI)
categories with the risk of sudden cardiac death (SCD) in a systematic review and meta …

Cardiac ion channel regulation in obesity and the metabolic syndrome: relevance to long QT syndrome and atrial fibrillation

AS Aromolaran, M Boutjdir - Frontiers in physiology, 2017 - frontiersin.org
Obesity and its associated metabolic dysregulation leading to metabolic syndrome is an
epidemic that poses a significant public health problem. More than one-third of the world …

Acquired long QT syndrome in chronic kidney disease patients

P Liu, L Wang, D Han, C Sun, X Xue, G Li - Renal Failure, 2020 - Taylor & Francis
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic
kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired …

CaMKII activation promotes cardiac electrical remodeling and increases the susceptibility to arrhythmia induction in high-fat diet–fed mice with hyperlipidemia …

P Zhong, D Quan, Y Huang… - Journal of cardiovascular …, 2017 - journals.lww.com
Background: Obesity/hyperlipidemia is closely related to both atrial and ventricular
arrhythmias. CaMKII, a multifunctional serine/threonine kinase, has been involved in cardiac …

Perivascular adipose tissue and coronary vascular disease

MK Owen, JN Noblet, DJ Sassoon… - … , and vascular biology, 2014 - Am Heart Assoc
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that
normally surrounds the major coronary arteries on the surface of the heart. Although …