Minamata disease in Japan and the large-scale poisoning by methylmercury (MeHg) in Iraq
caused wide public concerns about the risk emanating from mercury for human health …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Neural tube defects (NTDs), including anencephaly and spina bifida, are common major
malformations of fetal development resulting from incomplete closure of the neural tube …

The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a
test battery covering most of the relevant adverse outcome pathways may close this gap …

Retinol is a fat-soluble vitamin that plays an essential role in many biological processes
throughout the human lifespan. Here, we perform the largest genome-wide association …

The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up
and has presented substantial evidences for the role of RNA modifications in diseases. In …

Hazard assessment, based on new approach methods (NAM), requires the use of batteries
of assays, where individual tests may be contributed by different laboratories. A unified …

Background The exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …