A label-free impedometric biosensor has been developed for the detection of estrogen
hormone 17β-estradiol. The electrochemical biosensor has been fabricated by immobilizing …

Purpose: The purpose of this investigation is to determine the effects of physiologic levels
(10-50 nmol/L) of 2-methoxyestradiol (2ME) on the growth of estrogen receptor (ER) …

The proprotein convertase furin requires the pH gradient of the secretory pathway to
regulate its multistep, compartment-specific autocatalytic activation. Although His-69 within …

In this manuscript, we modulate the binding properties of estrogen receptor protein by
rationally modifying the amino acid composition of its ligand binding domain. By combining …

Human serum albumin (HSA) is an important protein that carries variety of substances like
some hormones and drugs in blood. Pharmacological studies of the interaction of many …

In this work, we demonstrate a novel estrogenic receptor fragment-based homogeneous
fluorescent assay which enables rapid and sensitive detection of 17β-estradiol (E2) and …

Pin1 is a two-domain enzyme which has peptidyl–prolyl cis/trans isomerase activity. Pin1
recognizes phospho-Ser/Thr-Pro motifs in cell-signaling proteins, and is both a cancer and …

The ligand binding domain (LBD) of nuclear hormone receptors adopts a very compact,
mostly α-helical structure that binds specific ligands with very high affinity. We use circular …

Among hormone-inducible transcription factors, estrogen receptors (ERs) play important
roles in tissue growth and differentiation, via either direct or indirect binding, in the nucleus …

X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy have proved
powerful methods for studying the structure of the isolated ligand and DNA-binding domains …