Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Testosterone and cardiovascular disease

RA Kloner, C Carson, A Dobs, S Kopecky… - Journal of the American …, 2016 - jacc.org
Testosterone (T) is the principal male sex hormone. As men age, T levels typically fall.
Symptoms of low T include decreased libido, vasomotor instability, and decreased bone …

Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline

S Bhasin, GR Cunningham, FJ Hayes… - The Journal of …, 2010 - academic.oup.com
Objective: Our objective was to update the guidelines for the evaluation and treatment of
androgen deficiency syndromes in adult men published previously in 2006. Participants …

Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis

MM Fernández-Balsells, MH Murad… - The Journal of …, 2010 - academic.oup.com
Context: The risks of testosterone therapy in men remain poorly understood. Objective: The
aim of this study was to conduct a systematic review and meta-analyses of testosterone trials …

Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis

G Corona, E Maseroli, G Rastrelli… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Recent reports have significantly halted the enthusiasm regarding androgen-
boosting; suggesting that testosterone supplementation (TS) increases cardiovascular (CV) …

Meta-analysis of results of testosterone therapy on sexual function based on international index of erectile function scores

G Corona, G Rastrelli, A Morgentaler, A Sforza… - European urology, 2017 - Elsevier
Context The interpretation of available clinical evidence related to the effect of testosterone
(T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of …

Association of testosterone treatment with alleviation of depressive symptoms in men: a systematic review and meta-analysis

A Walther, J Breidenstein, R Miller - JAMA psychiatry, 2019 - jamanetwork.com
Importance Countering depressive disorders is a public health priority. Currently,
antidepressants are the first-line treatment, although they show modest effects. In men …

A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment—a systematic review

AM Isidori, J Buvat, G Corona, I Goldstein, EA Jannini… - European urology, 2014 - Elsevier
Context Androgen modulation of erectile function (EF) is widely accepted. However, the use
of testosterone replacement therapy (TRT) in men with erectile dysfunction (ED) has …

Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline

S Bhasin, GR Cunningham, FJ Hayes… - The Journal of …, 2006 - academic.oup.com
Objective: The objective was to provide guidelines for the evaluation and treatment of
androgen deficiency syndromes in adult men. Participants: The Task Force was composed …

Testosterone supplementation and sexual function: a meta-analysis study

G Corona, AM Isidori, J Buvat, A Aversa… - The journal of sexual …, 2014 - academic.oup.com
Introduction The role of testosterone supplementation (TS) as a treatment for male sexual
dysfunction remains questionable. Aim The aim of this study was to attempt a meta-analysis …