Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Saponin adjuvants have been extensively studied for their use in veterinary and human
vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating …

Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or
steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal …

Numerous triterpenoid saponins are adjuvants that modify the activities of T cells and
antigen-presenting cells, like dendritic cells (DCs). Saponins can induce either …

This review is the ninth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring Momordica
saponin and capable of stimulating antigen-specific humoral and cellular immune …

We have designed and synthesized two analogs (5 and 6) of QS-7, a natural saponin
compound isolated from Quillaja saponaria (QS) Molina tree bark. The only structural …

We have derivatized Momordica saponins (MS) I and II through their coupling at C3
glucuronic acid site with dodecylamine. The derivatives show significantly different …

We have prepared a number of saponin-based vaccine adjuvant candidates. These
unnatural saponins have a different terminal-functionalized side chain incorporated into the …

Adjuvants can increase the magnitude and durability of the immune response generated by
the vaccine antigen. Aluminum salts (Alum) remain the main adjuvant licensed for human …