► Detailed survey of experimental and modeling approaches to cellular rhythms.► Cellular
rhythms in development: from cAMP oscillations to the segmentation clock.► Frequency …

BACKGROUND: Ca2+ is a ubiquitous and versatile second messenger that transmits
information through changes of the cytosolic Ca2+ concentration. Recent investigations …

Usually, the occurrence of random cell behavior is appointed to small copy numbers of
molecules involved in the stochastic process. Recently, we demonstrated for a variety of cell …

Cellular signaling operates in a noisy environment shaped by low molecular concentrations
and cellular heterogeneity. For calcium release through intracellular channels–one of the …

In computational neuroscience integrate-and-fire models capture the spike generation by a
subthreshold dynamics supplemented by a simple fire-and-reset rule; they allow for a …

Abstract Inositol 1, 4, 5-trisphosphate-induced Ca 2+ signaling is a second messenger
system used by almost all eukaryotic cells. The agonist concentration stimulating Ca 2+ …

Complexity and limited knowledge render it impractical to write down the equations
describing a cellular system completely. Cellular biophysics uses hypotheses-based …

In nonexcitable cells, global Ca 2+ spikes emerge from the collective dynamics of clusters of
Ca 2+ channels that are coupled by diffusion. Current modeling approaches have opposed …

Abstract Inositol 1, 4, 5-trisphosphate (IP 3)-induced Ca 2+ signaling is a second messenger
system used by almost all eukaryotic cells. Recent research demonstrated randomness of …

Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular
processes. Biological systems have developed regulatory mechanisms to ensure …