Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific
immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such …

The role of the gut microbiome in models of inflammatory and autoimmune disease is now
well characterized. Renewed interest in the human microbiome and its metabolites, as well …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia,
but it remains unclear how dietary salt harms the brain. We report that, in mice, excess …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Sodium accumulates in the interstitium and promotes inflammation through poorly defined
mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through …

A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular
disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells …

Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

A vast number of studies have demonstrated a remarkable role for the gut microbiota and
their metabolites in the pathogenesis of inflammatory diseases, including multiple sclerosis …