Doxorubicin (DOX) is a chemotherapeutic agent with marked, dose-dependent cardiotoxicity
that leads to tachycardia, atrial and ventricular arrhythmia, and irreversible heart failure …

Doxorubicin (DOX) is an anthracycline chemotherapy drug used in the treatment of various
types of cancer. However, short-term and long-term cardiotoxicity limits the clinical …

Background Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone, but can appear
surface bound on cancers cells, including ovarian cancers (OC). We investigated at what …

Doxorubicin (DOX) is used as an anticancer drug despite its many side effects.
Thymoquinone (THQ) is a plant-derived substance that exhibits antioxidant and anti …

Background As a natural isoquinoline alkaloid, palmatine (PLT) has been proven to play a
protective role against a variety of cardiovascular diseases. However, little research on the …

Background Doxorubicin (DOX) is a highly effective chemotherapeutic that is effective for
various tumours. However, the clinical application of DOX has been limited by adverse …

The endoplasmic reticulum (ER) is responsible for structural transformation or folding of de
novo proteins for transport to the Golgi. When the folding capacity of the ER is exceeded or …

Abstract Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role
in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated …

The usage of doxorubicin is hampered by its life‐threatening cardiotoxicity in clinical
practice. Dexrazoxane is the only cardioprotective medicine approved by the FDA for …

As a chemotherapy agent, doxorubicin is used to combat cancer. However, cardiotoxicity
has limited its use. The existing strategies fail to eliminate doxorubicin-induced …