Introduction: Cortisol effects on the brain are exerted through two distinct receptors, inducing
complex and even opposite effects on the cerebral structures implicated in the various …

There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Microglia mediate chronic neuroinflammation following central nervous system (CNS)
disease or injury, and in doing so, damage the local brain environment by impairing …

With severe injury or disease, microglia become chronically activated and damage the local
brain environment, likely contributing to cognitive decline. We previously discovered that …

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically,
however most mouse models of the disease harbor pathogenic mutations, rendering them …

Omega-3 polyunsaturated fatty acids (n‐3-PUFAs), mainly eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), may improve or prevent some psychiatric and …