Machine learning enables new insights into genetic contributions to liver fat accumulation

ME Haas, JP Pirruccello, SN Friedman, M Wang… - Cell genomics, 2021 - cell.com
Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …

Cross-modal autoencoder framework learns holistic representations of cardiovascular state

A Radhakrishnan, SF Friedman, S Khurshid… - Nature …, 2023 - nature.com
A fundamental challenge in diagnostics is integrating multiple modalities to develop a joint
characterization of physiological state. Using the heart as a model system, we develop a …

Established and novel risk factors for 30-day readmission following total knee arthroplasty: a modified Delphi and focus group study to identify clinically important …

D Gould, M Dowsey, T Spelman, J Bailey… - Journal of Clinical …, 2023 - mdpi.com
Thirty-day readmission following total knee arthroplasty (TKA) is an important outcome
influencing the quality of patient care and health system efficiency. The aims of this study …

[HTML][HTML] From local counterfactuals to global feature importance: efficient, robust, and model-agnostic explanations for brain connectivity networks

AL Alfeo, AG Zippo, V Catrambone… - Computer Methods and …, 2023 - Elsevier
Background: Explainable artificial intelligence (XAI) is a technology that can enhance trust in
mental state classifications by providing explanations for the reasoning behind artificial …

Trajectories of sentiment in 11,816 psychoactive narratives

SF Friedman, G Ballentine - … Psychopharmacology: Clinical and …, 2024 - Wiley Online Library
Objective Can machine learning (ML) enable data‐driven discovery of how changes in
sentiment correlate with different psychoactive experiences? We investigate by training …

Anticipatory detection of compulsive body-focused repetitive behaviors with wearables

BL Searle, D Spathis, M Constantinides… - Proceedings of the 23rd …, 2021 - dl.acm.org
Body-focused repetitive behaviors (BFRBs), like face-touching or skin-picking, are hand-
driven behaviors which can damage one's appearance, if not identified early and treated …

Right ventricular myocardial energetic model for evaluating right heart function in pulmonary arterial hypertension

JV Scott, TU Tembulkar, ML Lee, BT Faliks… - Physiological …, 2022 - Wiley Online Library
Background Pulmonary arterial hypertension (PAH) increases right ventricular (RV)
workload and decreases myocardial oxygen reserve, eventually leading to poor cardiac …

Mythological Medical Machine Learning: Boosting the Performance of a Deep Learning Medical Data Classifier Using Realistic Physiological Models

I Sadiq, EA Perez-Alday, AJ Shah, AB Rad… - arXiv preprint arXiv …, 2021 - arxiv.org
Objective: To determine if a realistic, but computationally efficient model of the
electrocardiogram can be used to pre-train a deep neural network (DNN) with a wide range …

A Novel Counterfactual-Based Global Feature Importance Measure to Reduce Computational Costs in Eeg-Based Explainable Ai Models

AL Alfeo, V Catrambone, G Valenza, M Cimino… - Available at SSRN … - papers.ssrn.com
By explaining the reasoning behind AI model outputs, Explainable artificial intelligence (XAI)
can build trust in AI-based brain-computer interfaces (BCI). Commonly used XAI approaches …

Computational Methods to Improve Clinical Decision Science Related to Pulmonary Arterial Hypertension

JV Scott - 2022 - search.proquest.com
Pulmonary arterial hypertension (PAH) remains a deadly and rare disorder of the pulmonary
vasculature. A combination of vasoconstriction and cellular proliferation of the pulmonary …