5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …

To aid surgeons in more complete and safe resection of brain tumors, adjuvant technologies
have been developed to improve visualization of target tissue. Fluorescence-guided surgery …

The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging.
However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the …

5-Aminolevulinic acid (ALA) is a naturally occurring amino acid synthesized in all nucleated
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …

Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-
guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection …

Background Fluorescence-guided surgery (FGS) with indocyanine green (ICG) is
increasingly applied in pediatric surgical oncology. However, FGS has been mostly reported …

Objectives To determine the utility of 5‐aminolevulinic acid (5‐ALA) fluorescence for
resection of head and neck carcinoma. Methods In this prospective pilot trial, 5‐ALA was …

Despite decades of clinical trials and surgical advances, the most common high-grade
glioma, glioblastoma (GBM), remains an incurable disease with a dismal prognosis …

Background Achieving maximal functionally safe resection of gliomas located within the
eloquent speech areas is challenging, and there is a lack of literature on the combined use …

Introduction: Recent advances in tumor visualization have improved the extent of resection
(EOR) of primary and secondary tumors of the central nervous system, while limiting the …