Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Autodock vina adopts more accurate binding poses but autodock4 forms better binding affinity

NT Nguyen, TH Nguyen, TNH Pham… - Journal of Chemical …, 2019 - ACS Publications
The binding pose and affinity between a ligand and enzyme are very important pieces of
information for computer-aided drug design. In the initial stage of a drug discovery project …

Enzymatic late‐stage modifications: better late than never

E Romero, BS Jones, BN Hogg… - Angewandte Chemie …, 2021 - Wiley Online Library
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

AM Kloosterman, P Cimermancic, SS Elsayed… - PLoS …, 2020 - journals.plos.org
Microbial natural products constitute a wide variety of chemical compounds, many which can
have antibiotic, antiviral, or anticancer properties that make them interesting for clinical …

Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

J Santos-Aberturas, G Chandra… - Nucleic Acids …, 2019 - academic.oup.com
The rational discovery of new specialized metabolites by genome mining represents a very
promising strategy in the quest for new bioactive molecules. Ribosomally synthesized and …

The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics

RS Heath, RE Ruscoe, NJ Turner - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 up to July 2021 The market for cosmetics is consumer driven and the desire
for green, sustainable and natural ingredients is increasing. The use of isolated enzymes …

Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides

R Kozakai, T Ono, S Hoshino, H Takahashi… - Nature …, 2020 - nature.com
Fusions of fatty acids and peptides expand the structural diversity of natural products;
however, polyketide/ribosomally synthesized and post-translationally modified peptides …

Improving ligand‐ranking of AutoDock Vina by changing the empirical parameters

TNH Pham, TH Nguyen, NM Tam… - Journal of …, 2022 - Wiley Online Library
Abstract AutoDock Vina (Vina) achieved a very high docking‐success rate,, but give a rather
low correlation coefficient,, for binding affinity with respect to experiments. This low …

Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis

Y Zheng, X Xu, X Fu, X Zhou, C Dou, Y Yu, W Yan… - Structure, 2023 - cell.com
Structural diverse natural products like ribosomally synthesized and posttranslationally
modified peptides (RiPPs) display a wide range of biological activities. Currently, the …