Isatin hybrids and their anti-tuberculosis activity

Z Xu, S Zhang, C Gao, J Fan, F Zhao, ZS Lv… - Chinese Chemical …, 2017 - Elsevier
Tuberculosis (TB) is one of the most common and even fatal infectious diseases known to
mankind. Millions of new cases are reported every year over the world, and one-third of the …

[PDF][PDF] Anti-tubercular activity of isatin derivatives

T Aboul-Fadl, FAS Bin-Jubair - Int. J. Res. Pharm. Sci, 2010 - academia.edu
Tuberculosis TB re ai saog the orld s great public health challenges. Worldwide resurgence
of TB is due to two major problems: the acquired immunodeficiency syndrome (AIDS) …

Computational investigation on structural and reactive sites (HOMO-LUMO, MEP, NBO, NPA, ELF, LOL, RDG) identification, pharmacokinetic (ADME) properties and …

N Elangovan, R Sangeetha, S Sowrirajan… - Analytical Chemistry …, 2022 - Taylor & Francis
Abstract (E)-4-((4-chlorobenzylidene) amino) benzene sulfonamide molecule has been
optimized and characterized by DFT/B3LYP/6-311++ G (d, p) quantum computational …

Isatin derivatives with potential antitubercular activities

D Jiang, GQ Wang, X Liu, Z Zhang… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the
lungs but can spread to other vital organs. The re‐emergence and wide spread of new …

Synthesis, structure and biological activity of hydrazones derived from 2-and 4-hydroxybenzoic acid hydrazides

OA Nurkenov, SD Fazylov, ZB Satpaeva… - Chemical Data …, 2023 - Elsevier
The condensation reaction of 4-and 2-hydroxybenzoic acid hydrazides with substituted
benzaldehydes led to the formation of a series of hydrazones. The synthesis of hydrazones …

Isoniazid–phytochemical conjugation: A new approach for potent and less toxic anti‐TB drug development

SS Swain, SK Paidesetty, RN Padhy… - Chemical Biology & …, 2020 - Wiley Online Library
Mycobacterium tuberculosis (Mtb) causes one of the most grievous pandemic infectious
diseases, tuberculosis (TB), with long‐term morbidity and high mortality. The emergence of …

Discovery of novel isatin-based thiosemicarbazones: synthesis, antibacterial, antifungal, and antimycobacterial screening

M Hassan, R Ghaffari, S Sardari… - Research in …, 2020 - journals.lww.com
Background and purpose: A group of thiosemicarbazones were prepared and their
structures were confirmed by spectroscopic methods such as IR and H-NMR, mass …

Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H

N Raghav, M Singh - European Journal of Medicinal Chemistry, 2014 - Elsevier
In the past decade, the work on the identification of small molecular weight compounds as
inhibitors of cysteine proteases has been in focus. In this direction, we here present the …

[PDF][PDF] Synthesis and preliminary antimicrobial evaluation of Schiff bases of N-benzyl isatin derivatives

TH Shakir, MMJ Al-Mudhafar - Systematic Reviews in Pharmacy, 2020 - academia.edu
ABSTRACT Isatin (1H-indole-2, 3-dione) and its analogs are an important class of
heterocyclic compounds. N-benzyl isatins and Schiff bases of isatin analogs have been …

Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids

T Aboul-Fadl, HA Abdel-Aziz, A Kadi, A Bari, P Ahmad… - Molecules, 2011 - mdpi.com
A facile and efficient method for synthesis of fenamic acid hydrazides from their acids in one-
step reaction under microwave irradiation and solvent-free conditions was developed …